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Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source
Published on: May 29, 2021
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Chemical fragment arrays for rapid druggability assessment
1Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Christoph.Rademacher@mpikg.mpg.de and Department of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany.
Abstract:
Incorporation of early druggability assessment in the drug discovery process provides a means to prioritize target proteins for high-throughput screening. We present chemical fragment arrays as a method that is capable of determining the druggability of a given target with low protein and compound consumption, enabling rapid decision making during early phases of drug discovery.

