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Hypertension in the elderly.

T W Wilson1, M Dubois

  • 1Department of Pharmacology, University of Saskatchewan, Saskatoon.

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|October 1, 1989
PubMed
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High blood pressure in older adults is common and increases health risks. Treating hypertension in the elderly, including isolated systolic hypertension, offers significant benefits and outweighs potential harms.

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Forty percent of Canadians over 65 have high blood pressure (hypertension), increasing risks of stroke, heart failure, heart attack, and death.
  • Aging involves circulatory changes like increased vascular resistance and decreased cardiac output, contributing to hypertension.
  • Elderly hypertensives experience similar treatment benefits as younger individuals.

Purpose of the Study:

  • To review the risks and benefits of treating hypertension in individuals over 65.
  • To evaluate treatment strategies for both systolic-diastolic and isolated systolic hypertension in the elderly.
  • To highlight considerations for antihypertensive drug selection and potential interactions in older adults.

Main Methods:

  • Review of major clinical trials on hypertension treatment, including subsets of elderly patients.

Related Experiment Videos

  • Analysis of specific trials focused on elderly hypertensive populations.
  • Examination of drug classes, contraindications, and potential adverse effects in elderly patients.

    • Main Results:

    • Treatment of systolic-diastolic hypertension in the elderly provides benefits that outweigh harms.
    • Isolated systolic hypertension is a significant risk factor, comparable to systolic-diastolic hypertension.
    • Thiazides are effective but contraindicated in many elderly patients; calcium channel blockers offer an alternative.

    Conclusions:

    • Hypertension management in the elderly is crucial for reducing cardiovascular events.
    • Careful drug selection and monitoring for interactions and rapid blood pressure reduction are essential.
    • Further research is needed on the definitive impact of treating isolated systolic hypertension on mortality and morbidity.