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Poly(Limonene Thioether) Scaffold for Tissue Engineering.

Kristin M Fischer1, Kathy Ye Morgan1, Keith Hearon1

  • 1Harvard-MIT Division of Health Sciences and Technology, David H. Koch Institute for Integrative Cancer Researchand Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Advanced Healthcare Materials
|February 19, 2016
PubMed
Summary
This summary is machine-generated.

Poly(limonene thioether) (PLT32o) scaffolds offer superior in vivo structural integrity and cell retention compared to poly(glycerol sebacate) (PGS). This new biomaterial shows promise for tissue engineering requiring durable, elastomeric scaffolds.

Keywords:
biomaterialheart cellin vivothiol-ene polymer

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Poly(glycerol sebacate) (PGS) is an established biomaterial for tissue engineering.
  • There is a need for biomaterials that maintain structural integrity and cell viability in vivo over extended periods.

Purpose of the Study:

  • To synthesize and characterize a novel photocurable thiol-ene polymer, poly(limonene thioether) (PLT32o).
  • To evaluate the suitability of PLT32o for tissue engineering applications, comparing its performance to PGS in vitro and in vivo.

Main Methods:

  • Synthesis and characterization of PLT32o.
  • Fabrication of PLT32o into tissue engineering scaffolds (grids and multilayered structures).
  • In vitro cell culture (heart cells) and in vivo subcutaneous implantation studies.

Main Results:

  • PLT32o scaffolds demonstrated compliant, elastomeric mechanical properties similar to PGS.
  • PLT32o scaffolds supported heart cell seeding and culture effectively.
  • In vivo, PLT32o scaffolds maintained structural integrity and retained cells long-term, unlike PGS scaffolds.
  • PLT32o implants retained dry mass, while PGS implants lost significant mass.

Conclusions:

  • PLT32o is a promising photocurable polymer for tissue engineering.
  • PLT32o offers advantages over PGS for applications requiring sustained in vivo structural support and elastomeric properties.
  • The facile synthesis and processing of PLT32o further enhance its potential for tissue engineering.