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Circumferential strain of carotid arteries does not differ between patients with advanced coronary artery disease and

Karina Wierzbowska-Drabik1, Kamila Cygulska1, Urszula Cieślik-Guerra1

  • 1Chair and Cardiology Department, Medical University of Lodz, Lodz, Poland.

Advances in Medical Sciences
|February 19, 2016
PubMed

Insights

Circumferential strain (CS) of carotid arteries did not differentiate patients with advanced coronary artery disease from controls. While feasible, CS measurements require further study to establish clinical significance in vascular function assessment.

Area of Science:

  • Cardiovascular imaging
  • Vascular function assessment
  • Echocardiography

Background:

  • Speckle tracking echocardiography (STE) is a key tool for myocardial function analysis.
  • Circumferential strain (CS) of carotid arteries is emerging as a potential biomarker for vascular health.
  • Advanced coronary artery disease (CAD) significantly impacts overall vascular function.

Purpose of the Study:

  • To characterize and compare carotid artery CS in patients with three-vessel coronary artery disease (3VD) versus controls.
  • To evaluate the potential of CS as a novel indicator of vascular dysfunction in advanced CAD.
  • To assess the correlation between CS and pulse wave velocity (PWV).

Main Methods:

  • Comparison of CS in the common carotid arteries (CCA) of 25 patients with 3VD and 16 controls using STE.
  • Measurement of intima-media thickness (IMT) and plaque presence in carotid arteries.
  • Estimation of PWV in a subset of patients and correlation with CS.

Main Results:

  • No significant difference in mean CS of the CCA between 3VD patients and controls.
  • Higher prevalence of plaque and thicker IMT observed in the 3VD group.
  • No correlation found between CS and PWV, indicating distinct pathophysiological pathways.

Conclusions:

  • Global CS of the CCA does not differentiate between individuals with 3VD and controls, unlike IMT.
  • STE demonstrates good feasibility and concordance for CS measurements in carotid arteries.
  • The clinical utility of carotid artery CS for assessing vascular function in CAD requires further investigation.
Abstract

Keywords:
Carotid arteriesCircumferential strainCoronary diseaseEchocardiographyIntima-media thickness

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