Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improved the slow digestion property of maize starch using partially β-amylolysis.

Food chemistry·2014

Same author

Blend-modification of soy protein/lauric acid edible films using polysaccharides.

Food chemistry·2014

Same author

Structure and physicochemical properties of octenyl succinic esters of sugary maize soluble starch and waxy maize starch.

Food chemistry·2014

Same author

[Effects of left renal vein division on postoperative renal function during open repair of abdominal aortic aneurysm].

Zhonghua yi xue za zhi·2014

Same author

Association of four insulin resistance genes with type 2 diabetes mellitus and hypertension in the Chinese Han population.

Molecular biology reports·2014

Same author

Neuroprotective effect of pseudoginsenoside-f11 on a rat model of Parkinson's disease induced by 6-hydroxydopamine.

Evidence-based complementary and alternative medicine : eCAM·2014

Search research articles

Related Experiment Video

Updated: Mar 25, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

An Early-Stage Atherosclerosis Research Model Based on Microfluidics.

Wenfu Zheng¹, Rong Huang², Bo Jiang¹

¹Beijing Engineering Research Center for BioNanotechnology, CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, No.11 BeiYiTiao, ZhongGuanCun, Beijing, 100190, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)

|February 19, 2016

Summary

A new microfluidic model replicates early atherosclerosis (AS) in vitro, bridging cell culture and animal studies. This model revealed drug toxicity and validated nanoparticle effectiveness, aiding atherosclerosis research and drug development.

Keywords:

atherosclerosis blood vessels drug screening mechanics microfluidic chips

More Related Videos

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

Published on: July 19, 2024

Related Experiment Videos

Last Updated: Mar 25, 2026

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

A Model of Disturbed Flow-Induced Atherosclerosis in Mouse Carotid Artery by Partial Ligation and a Simple Method of RNA Isolation from Carotid Endothelium

Published on: June 22, 2010

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Procedure for the Development of Multi-depth Circular Cross-sectional Endothelialized Microchannels-on-a-chip

Published on: October 21, 2013

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

In Vitro Model Integrating Substrate Stiffness and Flow to Study Endothelial Cell Responses

Published on: July 19, 2024

Area of Science:

Biomedical Engineering
Cardiovascular Research
Microfluidics

Background:

The arterial microenvironment is crucial in atherosclerosis (AS) pathology.
Understanding the interplay between the arterial microenvironment and atherogenesis is limited by the gap between cell culture and animal models.

Purpose of the Study:

To develop a microfluidic atherosclerosis model that recapitulates early-stage AS.
To bridge the gap between traditional cell culture and animal experiments in AS research.

Main Methods:

Developed a microfluidic device to simulate physiological and AS-prone hemodynamic conditions.
Utilized the model to study endothelial cell (EC) responses in an atherogenic environment.
Assessed the cytotoxicity of the drug probucol and the anti-AS efficiency of platinum-nanoparticles (Pt-NPs).

Main Results:

The microfluidic model successfully recaptured atherogenic EC responses, outperforming traditional Petri dish cultures.
Significant cytotoxicity of probucol was observed on the model, aligning with clinical evidence.
Platinum-nanoparticles demonstrated anti-AS efficiency consistent with animal experiment findings.

Conclusions:

The microfluidic AS model effectively bridges the gap between in vitro and in vivo AS research.
This model shows promise for advancing fundamental AS research, facilitating drug screening, and supporting clinical trials.