Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Health system learning enables generalist neuroimaging models.

Nature medicine·2026
Same author

Data sparse inference of operator spatial reward models in uncertain environments.

Frontiers in robotics and AI·2026
Same author

The role of the tryptophan-rich allosteric network and sodium egress in GPCR activation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Learning neuroimaging models from health system-scale data.

Nature biomedical engineering·2026
Same author

Effect of Liver Metastases on Survival in Microsatellite-Stable Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors.

Cancer research communications·2026
Same author

Health system learning achieves generalist neuroimaging models.

Research square·2025

Related Experiment Video

Updated: Mar 25, 2026

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
07:50

An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

Published on: June 4, 2021

3.2K

Targeted Lesion Generation Through the Skull Without Aberration Correction Using Histotripsy.

Jonathan Sukovich, Zhen Xu, Yohan Kim

    IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
    |February 19, 2016
    PubMed
    Summary

    Histotripsy can create precise lesions through the skull without aberration correction. This breakthrough simplifies non-invasive transcranial ultrasound therapy by eliminating the need for complex correction systems.

    More Related Videos

    Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
    10:58

    Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

    Published on: September 27, 2020

    5.6K
    Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
    14:10

    Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

    Published on: December 15, 2010

    16.5K

    Related Experiment Videos

    Last Updated: Mar 25, 2026

    An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug
    07:50

    An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug

    Published on: June 4, 2021

    3.2K
    Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry
    10:58

    Targeted Neuronal Injury for the Non-Invasive Disconnection of Brain Circuitry

    Published on: September 27, 2020

    5.6K
    Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
    14:10

    Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

    Published on: December 15, 2010

    16.5K

    Area of Science:

    • Ultrasound Therapy
    • Biomedical Engineering
    • Acoustic Physics

    Background:

    • Transcranial ultrasound therapy typically requires sophisticated aberration correction techniques.
    • Histotripsy is a non-invasive ultrasound ablation method.

    Purpose of the Study:

    • To demonstrate histotripsy's capability in generating targeted lesions through intact human skullcaps.
    • To assess the feasibility of transcranial histotripsy without aberration correction.

    Main Methods:

    • Utilized a 500 kHz, 256-element hemispherical transducer to deliver histotripsy therapy.
    • Tested on three excised human skullcaps and red blood cell agarose tissue phantoms.
    • Employed short pulses (2 acoustic cycles) with estimated peak rarefactional pressures (p-)LE of 28-39MPa.

    Main Results:

    • Generated compact lesions (<1mm radius) through intact skullcaps without aberration correction.
    • Lesion formation was consistent at the transducer's geometric focus.
    • Demonstrated the ability to create multiple patterned lesions transcranially.

    Conclusions:

    • Histotripsy can effectively create targeted, compact lesions through the skullcap without aberration correction.
    • This technique simplifies transcranial ultrasound therapy.
    • Offers a potential advancement for non-invasive therapeutic applications.