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Impact of Depressive Symptoms on Conversion from Mild Cognitive Impairment Subtypes to Alzheimer's Disease: A

Jiro Kida1,2, Kiyotaka Nemoto3, Chiaki Ikejima4

  • 1Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.

Journal of Alzheimer'S Disease : JAD
|February 19, 2016
PubMed
Abstract

Insights

Amnestic mild cognitive impairment (aMCI) significantly increases Alzheimer's disease risk. Depressive symptoms exacerbate this risk in aMCI, but not in nonamnestic MCI (naMCI).

Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Longitudinal studies on mild cognitive impairment (MCI) subtypes and dementia subtypes yield contradictory results.
  • Comorbid depressive symptoms with MCI may elevate the risk for Alzheimer's disease (AD).

Purpose of the Study:

  • To longitudinally investigate the relationships between MCI subtypes and dementia subtypes.
  • To specifically examine the effect of comorbid depressive symptoms on these relationships in a Japanese rural community.

Main Methods:

  • A cohort of 802 non-demented participants underwent baseline and follow-up assessments.
  • Complementary log-log analysis assessed the risk of dementia and AD conversion in amnestic MCI (aMCI) versus nonamnestic MCI (naMCI) groups.
  • The impact of depressive symptoms on transitions from MCI to AD and from cognitive normality to MCI or AD was analyzed.

Main Results:

  • The aMCI group exhibited a significantly higher risk of developing dementia, particularly AD, compared to the naMCI group.
  • In the aMCI group, depressive symptoms increased AD risk; this effect was not observed in the naMCI group.
  • In cognitively normal individuals, depressive symptoms elevated the risk of developing aMCI, but not naMCI or AD.

Conclusions:

  • MCI subtyping, distinguishing between amnestic and nonamnestic forms, is valuable for identifying dementia and AD prodromes.
  • The differential impact of depressive symptoms suggests distinct relationships between depression and cognitive impairment in aMCI versus naMCI.
Keywords:
Alzheimer’s diseasecommunityconversiondepressive symptomsmild cognitive impairment

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