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Computed Tomography

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...

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Related Experiment Video

Updated: Mar 25, 2026

Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy

Micron-scale Resolution Optical Tomography of Entire Mouse Brains with Confocal Light Sheet Microscopy

Published on: October 8, 2013

X-ray propagation-based equally sloped tomography for mouse brain.

Yuqi Ren¹, Yudan Wang¹, Guangzhao Zhou¹

¹Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.

Journal of X-Ray Science and Technology

|February 19, 2016

Summary

X-ray propagation-based phase contrast imaging with equally sloped tomography (PPCI-EST) successfully imaged mouse brains, distinguishing grey and white matter. This technique offers a promising tool for fast, low-dose biomedical imaging.

Keywords:

X-ray propagation-based phase contrast imaging equally sloped tomography mouse brain

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A Micro-CT-based Method for Characterizing Lesions and Locating Electrodes in Small Animal Brains

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Published on: November 8, 2018

Area of Science:

Neuroimaging
Biomedical Imaging
Radiology

Background:

The brain's critical function necessitates advanced imaging techniques.
Current rodent brain imaging methods are insufficient.
Developing improved non-invasive imaging for brain research is crucial.

Purpose of the Study:

To apply X-ray propagation-based phase contrast imaging combined with equally sloped tomography (PPCI-EST) for non-destructive mouse brain investigation.
To evaluate the efficacy of PPCI-EST in visualizing fine brain structures.

Main Methods:

Utilized X-ray propagation-based phase contrast imaging (PPCI).
Employed equally sloped tomography (EST) for image reconstruction.
Applied the combined PPCI-EST technique to mouse brain specimens.

Main Results:

Successfully discriminated between grey and white matter based on subtle electron density differences.
Visualized intricate brain structures, including the corpus callosum (cc), optic chiasma (ox), and caudate putamen (CPu).
PPCI-EST significantly reduced the required number of projections compared to filtered back projection while maintaining high image quality.

Conclusions:

PPCI-EST demonstrates potential as a valuable tool for biomedical imaging.
The technique enables fast and low-dose phase-contrast imaging of biological samples.
This method advances non-destructive investigation of delicate biological structures like the brain.