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HLA-C*01 is a Risk Factor for Crohn's Disease

Eun Suk Jung1, Jae Hee Cheon, Ji Hyun Lee

  • 1*Department of Pharmacology, Brain Korea 21 PLUS Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea; †Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea; ‡Department of Oral Biology, College of Dentistry, Yonsei University, Seoul, Korea; §Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea; ‖Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, Korea; Departments of ¶Laboratory Medicine, and **Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Inflammatory Bowel Diseases
|February 19, 2016
PubMed
Summary

This study identifies HLA-C*01 as a key genetic factor contributing to Crohn's disease (CD) susceptibility in the Korean population. Genetic variations in human leukocyte antigens (HLAs) and TNFSF15 are confirmed as important in CD pathogenesis.

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