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Updated: Mar 25, 2026

Induction of Ischemic Stroke and Ischemia-reperfusion in Mice Using the Middle Artery Occlusion Technique and Visualization of Infarct Area

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Puerarin for ischaemic stroke.

Bian Liu¹, Yan Tan, Deren Wang

¹Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, Sichuan, China, 610041.

The Cochrane Database of Systematic Reviews

|February 19, 2016

Summary

This summary is machine-generated.

Puerarin treatment did not significantly reduce death or dependency in ischaemic stroke patients. However, it may improve neurological deficit recovery, though evidence quality is low, necessitating further research.

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Area of Science:

Neurology
Pharmacology
Traditional Chinese Medicine

Background:

Puerarin, a herbal medicine, is commonly used in China for treating ischaemic stroke.
Assessing the efficacy of puerarin in ischaemic stroke patients is crucial for evidence-based practice.

Purpose of the Study:

To evaluate the effects of puerarin on outcomes in patients with ischaemic stroke.

Main Methods:

Searched multiple databases including Cochrane Stroke Group Trials Register, CENTRAL, MEDLINE, EMBASE, AMED, and CBM-disc up to August 2015.
Included 20 randomized controlled trials (RCTs) or quasi-RCTs comparing puerarin with placebo or no placebo in ischaemic stroke patients.
Data extraction and quality assessment were performed independently by two reviewers.

Main Results:

Meta-analysis of 2 trials (164 participants) showed no significant reduction in death or dependency with puerarin (RR 0.79, 95% CI 0.45 to 1.36).
Meta-analysis of 16 trials (1305 participants) indicated that puerarin reduced the proportion of participants without neurological deficit improvement (RR 0.42, 95% CI 0.33 to 0.55).
No serious adverse effects were reported; however, the evidence quality was low due to incomplete reporting and short follow-up.

Conclusions:

Insufficient evidence exists to determine puerarin's effect on survival or dependency in ischaemic stroke.
High-quality, large-scale RCTs with long-term follow-up are required to establish the efficacy of puerarin.