Related Experiment Video
Updated: May 5, 2026

Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice
Published on: September 17, 2015
Relationship between the most proximal His bundle and the morphology of intracavitary pressure curves
P Alboni1, S Scarfó, G F Baggioni
1Division of Cardiology, Arcispedale S. Anna, Ferrara, Italy.
Insights
Accurate His bundle (HB) localization aids in modifying atrioventricular (AV) nodal conduction. This study correlates HB location with pressure curves, finding distinct H-V intervals for diagnostic and therapeutic leads.
Area of Science:
- Cardiology
- Electrophysiology
- Medical Devices
Background:
- Precise localization of the His bundle (HB) is crucial for diagnosing and treating atrioventricular (AV) nodal conduction abnormalities.
- Bipolar leads are used for diagnosis, while unipolar leads are employed for therapy.
Purpose of the Study:
- To investigate the relationship between the proximal His bundle's location and the morphology of intracavitary pressure curves.
- To compare diagnostic (bipolar) and therapeutic (unipolar) lead recordings in relation to pressure dynamics.
Main Methods:
- Continuous recording of bipolar and unipolar H-V intervals in 15 patients undergoing gradual catheter withdrawal from the right ventricle to the atrium.
- Simultaneous monitoring of intracavitary pressure curves to correlate with electrograms.
Main Results:
- Significant differences in longest and shortest H-V intervals were observed for both bipolar and unipolar recordings (P < 0.001).
- H deflection was consistently observed with unipolar recordings alongside pressure curves.
- Atrial H-V intervals were generally greater than transvalvular H-V intervals, particularly with unipolar leads, and H wave amplitude decreased towards the atrium.
Conclusions:
- The study establishes a correlation between His bundle electrograms and intracavitary pressure curves, aiding in precise localization.
- Findings support the use of different lead types for diagnostic and therapeutic interventions targeting the His bundle and AV conduction.
Abstract:
A precise localization of the most proximal His bundle (HB) is useful both for diagnostic and for therapeutic purposes, allowing the modification of atrioventricular (AV) nodal conduction. For selective diagnosis a bipolar lead is utilized; for therapy, a unipolar lead. The aim of the present study was to determine the relationship between the most proximal HB and the morphology of intracavitary pressure curves. In 15 patients (aged 64 +/- 10 years), both bipolar and unipolar H-V intervals were continuously recorded while gradually withdrawing the catheter, which detected the pressure at its tip, from the right ventricle to the atrium. The longest bipolar H-V was 55.5 +/- 13 ms and the shortest 44.5 +/- 11 ms (P less than 0.001); the longest unipolar H-V was 56.5 +/- 14 ms and the shortest 46.2 +/- 11 ms (P less than 0.001). During unipolar recording, H deflection was present in all patients at the same time as ventricular, transvalvular and atrial pressure curves; during bipolar recording, the H electrogram was not present in only one patient concomitantly with the atrial curve. During bipolar recording, the atrial H-V interval was greater than transvalvular H-V in nine patients (mean differences: 6 +/- 2 ms) and they were equal in five; with unipolar recording the atrial H-V interval was greater than transvalvular H-V in 13 patients (mean difference: 8 +/- 6 ms) and they were equal in two. In all patients, the H wave amplitude diminished from the transvalvular area to the atrial one.(ABSTRACT TRUNCATED AT 250 WORDS)
Related Concept Videos
Bernoulli's Equation
Bernoulli's Principle
Bernoulli's principle has several...
Bernoulli's Principle: Applications
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:
Generalized Hooke's Law
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
Bernoulli's Equation for Flow Normal to a Streamline
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...

