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Updated: Mar 25, 2026

Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1
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Evaluating the Angiogenetic Properties of Ovarian Cancer Stem-Like Cells using the Three-Dimensional Co-Culture System, NICO-1

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Nitric oxide signaling in human ovarian cancer: A potential therapeutic target

Ahmed El-Sehemy1, Lynne-Marie Postovit2, YangXin Fu3

  • 1Department of Oncology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Nitric Oxide : Biology and Chemistry
|February 20, 2016
PubMed

Insights

Nitric oxide (NO) plays a key role in ovarian cancer development and progression. Targeting NO signaling offers a promising new therapeutic strategy for advanced ovarian cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Ovarian cancer is a leading cause of gynecologic cancer mortality globally.
  • Existing treatments for advanced ovarian cancer are often ineffective, necessitating novel therapeutic approaches.

Purpose of the Study:

  • To review the role of nitric oxide (NO) signaling in ovarian cancer.
  • To explore the therapeutic potential of targeting NO signaling for ovarian cancer treatment.

Main Methods:

  • Literature review of experimental and clinical studies.
  • Analysis of NO's multifaceted roles in cancer biology.

Main Results:

  • Nitric oxide (NO) is implicated in ovarian cancer growth, apoptosis, angiogenesis, and chemotherapy response.
  • NO signaling influences interactions between cancer and stromal cells.

Conclusions:

  • NO signaling is integral to ovarian cancer progression.
  • Targeting NO pathways presents a viable strategy for novel ovarian cancer therapies.
Keywords:
Diagnostic markerNitric oxideOvarian cancerTherapeutic targetiNOS

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