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Hormone-dependent brain development and neuroendocrine prophylaxis.

G Dörner1

  • 1Institute of Experimental Endocrinology, Humboldt University Medical School, Charité, Berlin/GDR.

Experimental and Clinical Endocrinology
|September 1, 1989
PubMed
Summary

Early life hormones and neurotransmitters shape brain development, influencing lifelong health. Environmental factors can disrupt this, causing permanent dysfunction, but early intervention can prevent many health issues.

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Area of Science:

  • Neuroendocrinology
  • Developmental Psychology
  • Teratology

Background:

  • Systemic hormones and neurotransmitters are critical organizers of brain development during early life.
  • The brain controls the neuro-endocrine-immune system, and its development influences lifelong feedback control systems.

Purpose of the Study:

  • To explain the origins of various idiopathic disorders by examining early life environmental influences on brain development.
  • To introduce the concept of functional teratology (teratopsychophysiology) alongside structural teratology.

Main Methods:

  • Review of existing literature on the role of hormones and neurotransmitters in early brain development.
  • Analysis of how environmental factors impact neurodevelopment and subsequent health outcomes.

Main Results:

  • Abnormal levels of hormones and neurotransmitters during critical developmental periods can act as teratogens.
  • These disruptions can lead to permanent physiological and psychological dysfunctions, explaining previously idiopathic conditions.

Conclusions:

  • Many unexplained health issues may stem from abnormal early-life psycho- and physiological processes.
  • Prevention is possible through optimizing the early environment or timely correction of hormonal/neurotransmitter imbalances.

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