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Related Concept Videos

Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Cardiac Catheterization II: Right Heart Catheterization01:21

Cardiac Catheterization II: Right Heart Catheterization

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Right Heart Catheterization: An OverviewRight heart catheterization is an invasive diagnostic procedure that measures right-sided cardiac and pulmonary artery pressures, calculates cardiac output, and identifies intracardiac shunts. It provides detailed hemodynamic data essential for diagnosing and managing various cardiovascular conditions, such as pulmonary hypertension.Access SitesCommon access sites for right heart catheterization include the internal jugular vein in the neck region, the...
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Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

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Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue,...
733
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

645
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
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Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

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Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
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Related Experiment Video

Updated: Mar 25, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
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Pressure-Flow During Exercise Catheterization Predicts Survival in Pulmonary Hypertension.

Elisabeth D Hasler1, Séverine Müller-Mottet1, Michael Furian1

  • 1Pulmonary Clinic, University Hospital Zurich, Zurich, Switzerland.

Chest
|February 20, 2016
PubMed
Summary

The pressure-flow relationship during exercise, specifically the mean pulmonary arterial pressure to cardiac output (mPAP/CO) ratio, predicts survival in pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) patients. This exercise hemodynamic marker offers valuable prognostic insight.

Keywords:
chronic thromboembolic pulmonary hypertensionexercisehemodynamicspulmonary arterial hypertensionpulmonary hypertension

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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Related Experiment Videos

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08:08

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Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension
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Characterization of the Isolated, Ventilated, and Instrumented Mouse Lung Perfused with Pulsatile Flow
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Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Hemodynamics

Background:

  • Pulmonary hypertension significantly impairs exercise capacity.
  • Investigating prognostic markers for pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) is crucial.

Purpose of the Study:

  • To determine if the mean pulmonary arterial pressure to cardiac output (mPAP/CO) relationship predicts transplant-free survival in PAH and inoperable CTEPH patients.
  • To assess the prognostic value of exercise hemodynamics in pulmonary hypertension.

Main Methods:

  • Right heart catheterization was performed at rest and during exercise in patients with PAH and CTEPH.
  • Transplant-free survival was analyzed using Kaplan-Meier and Cox regression.
  • The predictive value of various hemodynamic parameters, including mPAP/CO, was assessed.

Main Results:

  • Seventy patients (54 PAH, 16 CTEPH) were followed; 7-year survival was 59%.
  • Maximal workload, peak cardiac index, change in cardiac index, and mPAP/CO during exercise predicted survival.
  • The mPAP/CO ratio during exercise demonstrated strong predictive value for 3-year transplant-free survival (AUC 0.802).

Conclusions:

  • The exercise pressure-flow relationship, particularly mPAP/CO, predicts transplant-free survival in PAH and CTEPH.
  • Exercise hemodynamics provide important complementary prognostic information for managing pulmonary hypertension.
  • Right heart catheterization during exercise enhances the assessment of disease severity and outcome.