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The Association Between Circulating Levels of miRNA-181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1
Enas Samir Nabih1, Nevine Gamal Andrawes2
1Department of Medical Biochemistry, Faculty of Medicine, Ain Shams University, Cairo, Egypt. enassamer@hotmail.com.
Background:
miRNA-181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta-cells dysfunction.
Methods:
miRNA-181a expression was evaluated by real-time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age- and gender-matched healthy controls.
Results:
miRNA-181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C-peptide and SMAD7 levels.
Conclusion:
miRNA-181a appears to play a potential role in pancreatic beta-cells dysfunction via SMAD7.
