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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
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Drug Delivery Systems: Different Types01:27

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
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Updated: Mar 25, 2026

Increasing Durability of Dissociated Neural Cell Cultures Using Biologically Active Coralline Matrix
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Damage-tolerance strategies for nacre tablets.

Shengnan Wang1, Xinqiao Zhu1, Qiyang Li2

  • 1School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China.

Journal of Structural Biology
|February 20, 2016
PubMed
Summary

Nacre

Keywords:
DeformationEnergy dissipationIntracrystalline organicsNacreNanostructure

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Area of Science:

  • Materials Science
  • Biomimetics
  • Mechanical Engineering

Background:

  • Nacre, a natural composite, offers exceptional damage resistance.
  • Understanding nacre's structure-property relationships is key for biomimetic armor development.

Purpose of the Study:

  • Investigate the structure-mechanical performance links in nacre.
  • Identify nacre's toughening mechanisms for artificial armor inspiration.

Main Methods:

  • Analysis of nacre's hierarchical structure.
  • Examination of individual nacre tablet fracture behavior.
  • Study of intracrystalline organic influences on mechanical properties.

Main Results:

  • Nacre tablets, beyond their "brick-and-mortar" arrangement, localize damage.
  • Intracrystalline organics induce unique fracture patterns in nacre tablets.
  • Nanoscale deformation mechanisms enhance energy dissipation and structural integrity.

Conclusions:

  • Nacre's damage tolerance arises from individual tablet behavior and nanoscale mechanisms.
  • These findings provide insights for designing advanced artificial armors inspired by nacre.