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Related Concept Videos

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

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Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

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The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
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An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
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Imaging Studies for Cardiovascular System V: CT01:28

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Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
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Atherosclerosis III: Management01:26

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis
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Three-Dimensional Imaging of Aortic Tissues in Atherosclerosis

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Imaging Atherosclerosis.

Jason M Tarkin1, Marc R Dweck1, Nicholas R Evans1

  • 1From the Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK (J.M.T., A.J.B., J.H.F.R.); Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK (N.R.E.); Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom (M.R.D); Cardiac MR PET CT Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA (R.A.P.T., A.T.); Imaging Sciences Laboratories, Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, NY (Z.A.F., M.R.D.); and Department of Cardiology, Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, NY (Z.A.F.).

Circulation Research
|February 20, 2016
PubMed
Summary
This summary is machine-generated.

Atherosclerosis imaging offers advanced tools to analyze high-risk plaque and understand cardiovascular disease biology. Innovations are improving image acquisition and translation for better patient risk prediction and management.

Keywords:
atherosclerosiscoronary artery diseasemolecular imagingmultimodal imagingrisk factors

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Area of Science:

  • Cardiovascular Imaging
  • Vascular Biology
  • Translational Medicine

Background:

  • Atherosclerosis imaging technologies have advanced, offering tools to characterize high-risk plaque in vivo.
  • Beyond plaque characterization, these methods have significant scientific and translational potential.

Purpose of the Study:

  • To provide a comprehensive review of current and experimental atherosclerosis imaging methods.
  • To discuss their uses in research and potential for clinical translation.

Main Methods:

  • Multimodal imaging incorporating molecular probes and noninvasive techniques for plaque composition and activity analysis.
  • Intravascular imaging in catheterization labs for detailed tissue characterization and cap thickness measurement.
  • Integration with conventional anatomic and hemodynamic assessments.

Main Results:

  • Atherosclerosis imaging captures key biological data, aiding fundamental research and patient management strategies.
  • Imaging can quantify therapeutic response and predict cardiovascular risk.
  • Innovations are addressing barriers to clinical translation, including image acquisition and radiation exposure.

Conclusions:

  • Atherosclerosis imaging provides deep insights into plaque biology and disease burden.
  • These advanced imaging techniques hold significant promise for research, clinical translation, and improved cardiovascular risk prediction.