Spontaneous regression of large gastric carcinoid

Area of Science:

• Gastroenterology
• Endocrinology
• Oncology

Background:

• Carcinoid tumors are neuroendocrine neoplasms that can secrete hormones, leading to specific clinical syndromes.
• This case involves a patient with an epigastric carcinoid tumor presenting with elevated serum glucagon and urinary 5-hydroxyindoleacetic acid (5-HIAA).

Observation:

• The patient presented with an epigastric mass confirmed as a carcinoid tumor via biopsy.
• Despite refusing surgical intervention, the patient was monitored closely through regular follow-ups.
• Biomarker levels, including urinary 5-HIAA, were initially elevated, consistent with a functioning carcinoid tumor.

Findings:

• Over a one-year period, the carcinoid tumor demonstrated significant spontaneous regression in size.
• Clinical examination revealed the tumor was no longer palpable after one year.
• Ultrasound confirmed the complete resolution of the tumor, and urinary 5-HIAA levels normalized.

Implications:

• This case suggests that spontaneous regression of carcinoid tumors is possible, even in the presence of hormonal hypersecretion.
• It underscores the importance of long-term monitoring for patients with carcinoid tumors, particularly those who decline surgery.
• Further research is warranted to understand the mechanisms behind carcinoid tumor regression and its potential therapeutic implications.