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Pim-1 kinase as cancer drug target: An update

Yernar Tursynbay1, Jinfu Zhang2, Zhi Li3

  • 1Department of Biology, Nazarbayev University School of Science and Technology, Astana 010000, Republic of Kazakhstan.

Biomedical Reports
|February 20, 2016
PubMed

Insights

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) kinase regulates cell functions and is linked to cancer. This review highlights Pim-1

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase.
  • Aberrant Pim-1 kinase levels are associated with various cancers.
  • Pim-1 has distinct isoforms (Pim-1S and Pim-1L) with unique cellular functions.

Purpose of the Study:

  • To review the networks of Pim-1 kinase.
  • To focus on recent advances in Pim-1 as a novel cancer drug target.

Main Methods:

  • Literature review of recent studies on Pim-1 kinase.
  • Analysis of Pim-1's roles in cellular functions, cancer, and drug resistance.

Main Results:

  • Pim-1 regulates cell cycle, survival, and drug resistance.
  • Pim-1 isoforms exhibit distinct localization and functions (nuclear vs. plasma membrane).
  • Mitochondrial Pim-1 maintains mitochondrial integrity.
  • Emerging roles in immunotherapy, senescence bypass, metastasis, and epigenetics.

Conclusions:

  • Pim-1 kinase is a significant regulator of cellular processes.
  • Pim-1 is a promising drug target, especially for prostate cancer.
  • Ongoing research reveals novel functions of Pim-1 in cancer progression and treatment.
Keywords:
Pim-1drug targetmitochondrial Pim1update

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