Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

5.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.4K
Epigenetic Regulation01:37

Epigenetic Regulation

4.2K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
4.2K
Epigenetic Regulation01:46

Epigenetic Regulation

34.2K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
34.2K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

4.3K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.3K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.9K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.9K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

1.1K
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outpatient visit intervals in chronic kidney disease: adherence to Kidney Disease: Improving Global Outcomes recommendations and determinants of variation.

Kidney research and clinical practice·2026
Same author

Aerobic exercise capacity and incident chronic kidney disease in patients with heart failure with preserved ejection fraction.

Kidney research and clinical practice·2026
Same author

Colchicine attenuates kidney injury by modulating the NLRP3 inflammasome pathway.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Predicting Risk of Cardiovascular Disease EVENTs Equation for Adverse Cardio-Kidney Outcomes in CKD Population.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Multi expert integrated algorithm for kidney biopsy triage.

NPJ digital medicine·2026
Same author

Effectiveness and Safety of Finerenone in Patients With Diabetic Kidney Disease: A Real-World Observational Study.

Diabetes, obesity & metabolism·2026

Related Experiment Video

Updated: Mar 25, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

810

Epigenetic modifications and diabetic nephropathy.

Marpadga A Reddy1, Jung Tak Park1, Rama Natarajan1

  • 1Department of Diabetes, Beckman Research Institute of City of Hope, Duarte, California, USA.

Kidney Research and Clinical Practice
|February 20, 2016
PubMed
Summary
This summary is machine-generated.

Epigenetic mechanisms like histone lysine methylation may explain diabetic nephropathy's metabolic memory. Targeting these epigenetic changes offers potential new therapies for diabetes complications.

Keywords:
ChromatinDNA methylationDiabetic nephropathyEpigenomicsHistone modificationsMetabolic memory

More Related Videos

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.7K
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

1.0K

Related Experiment Videos

Last Updated: Mar 25, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:31

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

810
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
10:03

A Zebrafish Model of Diabetes Mellitus and Metabolic Memory

Published on: February 28, 2013

26.7K
Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease
08:15

Author Spotlight: Network Pharmacology and Molecular Docking to Decipher the Action of Jiawei Shengjiang San Against Diabetic Kidney Disease

Published on: May 10, 2024

1.0K

Area of Science:

  • Biochemistry
  • Genetics
  • Endocrinology

Background:

  • Diabetic nephropathy (DN) is a leading cause of end-stage renal disease in type 1 and type 2 diabetes.
  • Current treatments for DN are limited, partly due to an incomplete understanding of its gene regulation.
  • The 'metabolic memory' phenomenon, where prior hyperglycemia effects persist, challenges DN treatment.

Purpose of the Study:

  • To explore the role of epigenetic mechanisms in diabetic nephropathy pathogenesis.
  • To investigate the potential of epigenetic modifications in explaining the 'metabolic memory' of diabetes.
  • To identify potential epigenetic biomarkers and therapeutic targets for DN.

Main Methods:

  • Review of emerging evidence on epigenetic mechanisms (DNA methylation, histone modifications, noncoding RNAs) in diabetes.
  • Focus on histone lysine methylation's role in regulating fibrotic and inflammatory genes in DN.
  • Consideration of high-throughput genomics and epigenomics technologies.

Main Results:

  • Epigenetic mechanisms alter gene expression without changing DNA sequence.
  • Histone lysine methylation is implicated in regulating key genes in DN.
  • Evidence suggests histone lysine methylation persists after glucose control, linking it to metabolic memory.

Conclusions:

  • Epigenetic modifications, particularly histone lysine methylation, play a significant role in DN.
  • These epigenetic changes may underlie the persistent effects of hyperglycemia (metabolic memory).
  • Advances in epigenomics can identify biomarkers and novel therapeutic strategies for DN and other diabetes complications.