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Histopathological and Immunohistochemical Evaluation of Meningiomas with Reference to Proliferative Markers p53 and
Ramesh Babu Telugu1, Amit Kumar Chowhan2, Nandyala Rukmangadha2
1Assistant Professor, Department of Pathology, Christian Medical College Hospital , Vellore, Tamilnadu, India .
Introduction:
Meningiomas are slow growing primary central nervous system (CNS) tumours attached to the duramater, which arise from the meningothelial cells of the arachnoid. Grading of meningioma based on histological findings assisted with supplementary immunohistochemical studies, predicts the prognosis of meningioma with good precision.
Aim:
To evaluate proliferative markers and correlate with various histological subtypes and grade.
Materials And Methods:
A total of 224 meningiomas, diagnosed between January1995 and October 2011were graded according to WHO 2007 criteria. Immunostaining for p53 and Ki-67 markers were performed on 100 cases.
Results:
There was female predominance. There were 194 Grade I, 24 Grade II and 6 Grade III meningiomas. Brain invasion noted in 18(8%) meningiomas predominantly in grade III followed by grade II. Recurrence was seen in 7 (3.1%) cases, most common in psammomatous followed by angiomatous meningioma. Immunostaining showed p53 positivity in 72.5% of grade I, 83.3% of grade II and all the cases of grade III tumours. Ki-67 Labelling Index (LI) consistently increased from grade I to grade III tumours.
Conclusion:
p53 and Ki-67 LI correlated well with increasing histological grade and biological behaviour of meningioma.
Insights
Proliferative markers p53 and Ki-67 (Ki-67 LI) correlate with meningioma grade. Higher expression indicates increased tumor grade and suggests more aggressive biological behavior in these central nervous system tumors.
Area of Science:
- Neuropathology
- Oncology
- Molecular Pathology
Background:
- Meningiomas are slow-growing primary central nervous system (CNS) tumors arising from arachnoid meningothelial cells.
- Histological grading, supported by immunohistochemistry, accurately predicts meningioma prognosis.
Purpose of the Study:
- To evaluate the expression of proliferative markers p53 and Ki-67.
- To correlate these markers with different histological subtypes and grades of meningioma.
Main Methods:
- A total of 224 meningiomas diagnosed between 1995 and 2011 were graded using WHO 2007 criteria.
- Immunostaining for p53 and Ki-67 was performed on 100 cases.
Main Results:
- Meningiomas showed female predominance, with 194 Grade I, 24 Grade II, and 6 Grade III cases.
- Brain invasion and recurrence rates increased with higher tumor grades.
- p53 positivity was observed in 72.5% (Grade I), 83.3% (Grade II), and 100% (Grade III) of tumors.
- Ki-67 Labelling Index (LI) showed a consistent increase from Grade I to Grade III.
Conclusions:
- p53 and Ki-67 LI correlate strongly with increasing histological grade in meningiomas.
- These markers effectively predict the biological behavior and prognosis of meningiomas.
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