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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Various Possible Toxicants Involved in Thyroid Dysfunction: A Review.

Jagminder K Bajaj¹, Poonam Salwan², Shalini Salwan³

¹Professor and Head, Department of Pharmacology, PIMS , Jalandhar, India .

Journal of Clinical and Diagnostic Research : JCDR

|February 20, 2016

Summary

Environmental factors significantly impact thyroid dysfunction, especially in genetically susceptible individuals. Understanding these toxicants is crucial for reducing the global prevalence of thyroid disorders.

Keywords:

Goiter Hypothyroidism Thyroid Thyroid disorders

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Area of Science:

Endocrinology
Environmental Health
Toxicology

Background:

Thyroid gland dysfunction affects approximately 300 million people worldwide.
Environmental factors are key contributors to autoimmune thyroid diseases in susceptible individuals, with genetics accounting for 70% of risk.
Understanding environmental influences is vital for managing thyroid disorders, particularly for those with a family history.

Purpose of the Study:

To highlight potential environmental toxicants that affect thyroid function.
To inform strategies for controlling excessive exposure and reducing thyroid disorder prevalence.

Main Methods:

This article reviews existing knowledge on environmental agents and their association with thyroid dysfunction.
It emphasizes the importance of direct measurement of toxicant exposure in relation to an individual's thyroid status for ideal study design.

Main Results:

Environmental factors play a significant role in the causation of thyroid diseases.
Identifying and understanding these factors are essential for accurate interpretation of thyroid status studies.

Conclusions:

Comprehensive knowledge of environmental toxicants influencing thyroid function is necessary.
Implementing measures to control exposure to these agents can help lower the incidence of thyroid disorders.