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Updated: Mar 25, 2026
06:35
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
7.9K
Giant Cell Tumor of Bone - An Overview
Anshul Sobti1, Pranshu Agrawal1, Sanjay Agarwala1
1Department of Orthopaedics, P.D Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai, India.
The Archives of Bone and Joint Surgery
|February 20, 2016
Summary
Giant Cell Tumors (GCT) are benign bone tumors that can behave aggressively and metastasize. Treatment consensus is lacking, with surgical options ranging from intralesional approaches to wide resection.
Area of Science:
- Orthopedics
- Oncology
- Pathology
Background:
- Giant Cell Tumors (GCT) are typically benign bone neoplasms.
- They can exhibit aggressive local behavior and, rarely, metastasis.
- GCTs often occur in peri-articular locations, disrupting bone architecture.
Purpose of the Study:
- To summarize the current understanding of Giant Cell Tumors.
- To discuss the challenges in GCT treatment selection.
- To highlight the need for improved pathogenesis understanding for novel therapies.
Main Methods:
- Review of existing literature on Giant Cell Tumors.
- Analysis of histopathological characteristics.
- Evaluation of current and proposed treatment strategies.
Main Results:
- GCTs are characterized by mononuclear stromal cells and multinucleated giant cells.
- No consensus exists on optimal treatment; surgical options vary.
- Despite benign classification, lung metastases can occur with poor prognosis.
Conclusions:
- Giant Cell Tumors present a complex clinical challenge due to their unpredictable behavior.
- Surgical intervention is the primary treatment modality.
- Further research into GCT pathogenesis is crucial for developing targeted treatments.
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