Exploring the photochemosensitivity by novel cysteine-based mixed ligand complexes
Muthusamy Selvaganapathy1, Narayanaperumal Pravin1, Vellaichamy Muniyandi1
1Research Department of Chemistry, VHNSN College, Virudhunagar 626 001, Tamil Nadu, India.
Journal of Photochemistry and Photobiology. B, Biology
|February 20, 2016
Summary
New metal(II) complexes featuring cysteine and bipyridine/phenanthroline exhibit DNA binding and cleavage. Copper(II) complexes show promising in vitro anticancer and photocytotoxicity against human tumor cells.
Area of Science:
- Coordination chemistry
- Bioinorganic chemistry
- Medicinal chemistry
Background:
- Cysteine-based metal complexes are explored for biological applications.
- 2,2'-bipyridine and 1,10-phenanthroline are common ligands in coordination chemistry.
Purpose of the Study:
- Synthesize and characterize novel cysteine-based metal(II) complexes.
- Investigate their DNA binding, cleavage, and in vitro anticancer activities.
Main Methods:
- Complex synthesis and characterization using analytical and spectroscopic techniques.
- DNA binding studies via spectroscopic titration and viscosity measurements.
- DNA cleavage assays using electrophoresis and in vitro anticancer/photocytotoxicity tests.
Main Results:
- Eighteen octahedral metal(II) complexes were synthesized and characterized.
- Complexes bind to DNA via intercalation and efficiently cleave pBR322 DNA.
- Copper(II) complexes demonstrated in vitro anticancer activity and significant photocytotoxicity against MCF-7 cells.
Conclusions:
- The synthesized metal complexes possess DNA-binding and cleavage capabilities.
- Copper(II) complexes show potential as anticancer agents, particularly in photochemotherapy.
- These complexes warrant further investigation for therapeutic applications.
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