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Orchestration of B lymphoid cells and their inner myeloid by Bach

Kazuhiko Igarashi1, Ari Itoh-Nakadai2

  • 1Department of Biochemistry and Center for Regulatory Epigenome and Diseases, Tohoku University Graduate School of Medicine, Seiryo-machi 2-1, Sendai 980-8575, Japan.

Current Opinion in Immunology
|February 20, 2016
PubMed

The transcription repressor Bach2 is required for class switch recombination and somatic hypermutation of antibody genes in B cells, and proper development of effector and regulatory T cells. In addition, Bach2 and its related factor Bach1 promote B cell commitment of progenitor cells by repressing myeloid-related genes. Bach2 and the myeloid regulators C/EBPβ and C/EBPα mutually repress their expression, forming a gene regulatory network (GRN) that dictates the process of lineage commitment. Bach2 forms another GRN with the plasma cell regulator Blimp-1, in which Bach2 and Blimp-1 mutually repress their expression. Since Bach2 expression is reduced in plasma cells, the repression of myeloid-related genes in B cells may be dissolved upon terminal differentiation of B cells to plasma cells. The Bach2 GRNs support the myeloid-based model of hematopoiesis. Myeloid-like characteristics suppressed or manifested in B cells by modifying differentiation trajectories of B and myeloid cells may be termed as 'inner myeloid' after the concept of 'inner fish'.

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