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Updated: Mar 25, 2026

Biofunctionalization of Magnetic Nanomaterials
Published on: July 16, 2020
On the accessibility of surface-bound drugs on magnetic nanoparticles. Encapsulation of drugs loaded on modified
Natesan Sudha1, Sameena Yousuf1, Enoch V M V Israel2
1Department of Chemistry, Karunya University, Coimbatore 641 114, Tamil Nadu, India.
Abstract:
We report the loading of drugs on aminoethylaminodextran-coated iron oxide nanoparticles, their superparamagnetic behavior, loading of drugs on them, and the β-cyclodextrin-complex formation of the drugs on the surface of the nanoparticles. The magnetic behavior is studied using vibrating sample magnetometry and X-ray photoelectron spectroscopy is used to analyze the elemental composition of drug-loaded nanoparticles. Scanning electron microscopy shows ordered structures of drug-loaded nanoparticles. UV-visible absorption and fluorescence spectroscopy are used to study the binding of the surface-loaded drugs to β-cyclodextrin. All of the drugs form 1:1 host-guest complexes. The iodide ion quenching of fluorescence of free- and iron oxide-attached drugs are compared. The binding strengths of the iron oxide surface-loaded drugs-β-cyclodextrin binding are smaller than those of the free drugs.
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