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Updated: Mar 25, 2026

Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
Innovative hybrid vs polymeric nanocapsules: The influence of the cationic lipid coating on the "4S"
C Carbone1, D Manno2, A Serra2
1Laboratory of Drug Delivery Technology, Department of Drug Sciences, University of Catania, V.le A. Doria 6, 95125 Catania, Italy; NANO-i-Research Centre On Ocular Nanotechnology-University of Catania, Catania, Italy.
Abstract:
Polymeric and hybrid aqueous-core nanocapsules were prepared using a low energy organic-solvent free procedure as innovative nanodevices for the ophthalmic delivery of melatonin. In order to evaluate how different cationic lipids could affect the main properties of the nanodevices, we focused our attention on mean particles size, surface charge, shape and stability (the "4S"). The results of our study confirmed the hypothesis that the coating material differently affects the overall nanoparticles properties, above all in terms of morphology: in particular, the cationic lipid dimethyldioctadecylammonium bromide allows the formation of very stable well-defined nanocapsules with non-spherical shape with sustained and prolonged drug release, thus representing a great advantage in ophthalmic application.
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