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Microperfusion Technique to Investigate Regulation of Microvessel Permeability in Rat Mesentery
Published on: September 12, 2015
Vessel sealing comparison: old school is still hip
Sasha J Tharakan1, Dennis Hiller2, Rachel M Shapiro2
1Division of General, Thoracic, and Fetal Surgery, Children's Hospital of Philadelphia, 3401 Civic Center Blvd, Philadelphia, PA, 19104, USA. tharakans@email.chop.edu.
Suture-based surgical vessel closure methods demonstrated superior strength compared to mechanical and energy devices in ex vivo pressure tests. All tested methods exceeded physiologically relevant pressures, ensuring safe vessel sealing.
Area of Science:
- Surgical Technology
- Biomedical Engineering
- Vascular Surgery
Background:
- Traditional vessel ligation uses sutures, but new sealing technologies are emerging.
- Limited objective data exists comparing the efficacy of various vessel sealing methods.
- Surgical closure of vessels is critical for hemostasis.
Purpose of the Study:
- To objectively compare diverse surgical vessel sealing methods.
- To evaluate sealing strength using a standardized ex vivo pressure challenge.
- To provide data on the performance of mechanical and energy-based vessel sealing devices.
Main Methods:
- Ten common surgical sealing devices (mechanical and energy) were tested.
- Porcine carotid arteries were used in a reproducible ex vivo setup.
- Arteries were pressurized until sealing failure, with maximum pressure recorded.
Main Results:
- 184 trials assessed 10 different vessel sealing methods.
- Average burst pressure was 1100 mmHg, ranging from 51.3 to 5171 mmHg.
- Suture-based methods showed the highest burst pressures, while stapling methods showed the lowest.
Conclusions:
- Ex vivo testing revealed significant variations in sealing strength among methods.
- All tested hemostatic modalities safely secured vessels above physiologic pressures.
- Suture-based methods were significantly stronger than mechanical and energy devices.
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