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Glia Maturation Factor-γ Regulates Monocyte Migration through Modulation of β1-Integrin

Wulin Aerbajinai1, Lunhua Liu2, Jianqiong Zhu1

  • 1From the Molecular and Clinical Hematology Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 and.

The Journal of Biological Chemistry
|February 21, 2016
PubMed
Summary

Glia maturation factor-gamma (GMFG) is crucial for monocyte migration and adhesion by regulating β1-integrin turnover. GMFG prevents integrin degradation and promotes recycling, essential for immune cell movement.

Keywords:
Arp2/3 complexadhesioncell migrationendocytosisglia maturation factor-gamma (GMFG)integrinubiquitylation (ubiquitination)

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