Related Experiment Video
Updated: Mar 25, 2026

Precision Induction and Distinction of Coughing and Sneezing Reflexes in Mice
Published on: October 3, 2025
A curious fact: Photic sneeze reflex. Autosomical dominant compelling helio-ophthalmic outburst syndrome
C Sevillano1, A Parafita-Fernández1, V Rodriguez-Lopez2
1Servicio de Oftalmología, Complejo Hospitalario de Pontevedra, Pontevedra, Spain.
Objective:
To assess ocular involvement in the pathophysiology of autosomal dominant compelling helio-ophthalmic outburst syndrome (ACHOOs).
Methods:
An interview was conducted with a Caucasian family that showed clinical features of ACHOOs. Twelve of them had photic reflex and were recruited. A complete eye evaluation was made.
Results:
A dominant autosomal inheritance with mild penetrance was demonstrated, with 67% of the studied subjects showing some degree of prominent corneal nerves. No other eye changes were found.
Conclusions:
Prominent corneal nerves may be associated with ACHOOs. The other eye structures studied do not seem to play a role in ACHOOs. Further studies are needed to understand the physiology of the ACHOOs.
Related Concept Videos
Somatic Spinal Reflexes
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
The Micturition Reflex
The process begins with bladder filling, where the bladder wall stretches as urine accumulates. This stretching activates the urine storage reflex, mediated by the sacral spinal segments and the pontine storage center. Efferent sympathetic impulses stimulate the detrusor muscle to relax and the internal urethral sphincter to contract, facilitating...
Reflex Activity
A reflex exam is a diagnostic procedure performed by a healthcare professional to evaluate the functionality of a patient's...
Channel Rhodopsins
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...
Facial Feedback Hypothesis
Focusing of Light in the Eye

