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Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Chronic Pancreatitis I: Introduction

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Related Experiment Video

Updated: Mar 25, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

Probable doxycycline-induced acute pancreatitis.

Brian T Moy¹, Nikhil Kapila²

¹Department of Medicine, University of Connecticut Health Center-Farmington, Farmington, CT. moy@uchc.edu.

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists

|February 21, 2016

Summary

Doxycycline can cause acute pancreatitis (AP), a serious condition. This case highlights a probable link between doxycycline use and AP, emphasizing the need for vigilance with this antibiotic.

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Area of Science:

Pharmacology
Gastroenterology
Toxicology

Background:

Antibiotics are crucial for treating bacterial infections.
Doxycycline, a tetracycline antibiotic, is widely prescribed.
Adverse drug reactions can range from mild to life-threatening.

Observation:

A 51-year-old male presented with severe fatigue, confusion, and abdominal tenderness.
He recently started doxycycline for suspected Lyme disease.
Laboratory results revealed significantly elevated lipase and amylase levels, indicative of pancreatitis.

Findings:

Abdominal CT confirmed acute pancreatitis (AP).
Other potential causes for AP were ruled out.
A Naranjo scale score of 6 indicated a probable adverse reaction to doxycycline.

Implications:

This case adds to the evidence linking doxycycline to AP.
Clinicians should consider AP in patients presenting with compatible symptoms after doxycycline initiation.
Prompt discontinuation of the drug and supportive care are crucial for recovery.