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Updated: Mar 25, 2026

X-Ray Crystallography to Study the Oligomeric State Transition of the Thermotoga maritima M42 Aminopeptidase TmPep1050
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Tip110: Physical properties, primary structure, and biological functions.

Amanda Whitmill1, Khalid Amine Timani1, Ying Liu1

  • 1Department of Cell Biology and Immunology, Graduate School of Biomedical Sciences, University of North Texas Health Science Center, Fort Worth, TX 76107, United States.

Life Sciences
|February 21, 2016
PubMed
Summary
This summary is machine-generated.

HIV-1 Tat-interacting protein of 110kDa (Tip110) has diverse roles in gene regulation and development. This review summarizes Tip110

Keywords:
DevelopmentGene transcriptionHIV replicationPost-translational modificationsPre-mRNA splicingStem cell biologyTip110

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • HIV-1 Tat-interacting protein of 110kDa (Tip110), also known as Sart3, was initially identified without defined functions.
  • Over two decades, Tip110 has been linked to crucial cellular processes including pre-mRNA splicing, gene transcription, and stem cell biology.
  • Altered Tip110 expression is implicated in cancer and other human diseases, highlighting its clinical relevance.

Purpose of the Study:

  • To consolidate existing literature on the gene/protein Tip110.
  • To provide a comprehensive overview of Tip110's diverse biological functions.
  • To highlight the evolving understanding of Tip110's role in health and disease.

Main Methods:

  • Literature review of scientific publications on Tip110/Sart3.
  • Analysis of studies detailing Tip110's involvement in molecular and cellular processes.
  • Synthesis of data on Tip110's role in development and disease pathogenesis.

Main Results:

  • Tip110 participates in pre-mRNA splicing and gene transcription.
  • Tip110 is involved in stem cell maintenance and developmental processes.
  • Tip110 dysregulation is associated with various human pathologies, including cancer.

Conclusions:

  • Tip110 is a multifunctional protein with critical roles in fundamental biological processes.
  • Further research into Tip110 is essential for understanding its contribution to human health and disease.
  • Tip110 represents a promising target for therapeutic interventions in cancer and other diseases.