Related Experiment Video

Updated: Mar 25, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

765

Phase angle is associated with advanced fibrosis in patients chronically infected with hepatitis C virus

Mariana de Souza Dorna1, Livia Alves Amaral Santos1, Fernanda Futino Gondo1

  • 1Department of Internal Medicine, Botucatu Medical School, UNESP - Univ Estadual Paulista, Botucatu, Brazil.

Life Sciences
|February 21, 2016
PubMed

Insights

Phase angle (PhA) predicts advanced liver fibrosis in hepatitis C virus (HCV) patients. A decrease in PhA significantly increases the risk of developing advanced liver fibrosis.

Area of Science:

  • Hepatology
  • Biomarkers
  • Clinical Diagnostics

Background:

  • Chronic hepatitis C virus (HCV) infection is a significant cause of liver disease.
  • Advanced liver fibrosis is a critical determinant of patient prognosis and treatment decisions.
  • Non-invasive markers for assessing liver fibrosis are highly sought after.

Purpose of the Study:

  • To investigate the association between phase angle (PhA) and advanced liver fibrosis in patients with chronic HCV infection.
  • To determine if PhA can serve as a predictor of significant liver fibrosis.

Main Methods:

  • Prospective evaluation of 135 patients with chronic HCV infection.
  • Bioelectrical impedance analysis (BIA) to measure PhA.
  • Analysis of biochemical markers and liver biopsy data for fibrosis staging.

Main Results:

  • Phase angle (PhA) was found to be a significant predictor of advanced liver fibrosis (OR: 0.227; p: 0.013).
  • Lower PhA values were associated with older age, increased insulin resistance, and higher inflammation.
  • Optimal PhA cut-off points for advanced fibrosis were identified as 6.43° overall, 5.94° for females, and 6.72° for males.

Conclusions:

  • Phase angle (PhA) is a valuable predictor of advanced liver fibrosis in patients with chronic HCV.
  • A one-degree decrease in PhA was associated with a greater than four-fold increase in the risk of advanced fibrosis.
  • PhA measurement via BIA offers a potential non-invasive tool for fibrosis assessment in HCV patients.
Abstract

Keywords:
Bioelectrical impedanceHepatitis C virusLiver fibrosis

More Related Videos

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI06:09

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

Published on: July 21, 2023

2.1K
Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis05:56

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

677

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
333
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
34
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
871
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
256
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
1.0K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
475