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Related Concept Videos

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
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Pituitary aspergillus infection.

Lauren A Moore1, Emily M Erstine1, Richard A Prayson1

  • 1Cleveland Clinic Department of Anatomic Pathology, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|February 22, 2016
PubMed
Summary

Fungal infections, though rare, can affect the pituitary gland and sella. This case highlights Aspergillus infection in a 74-year-old man, emphasizing the need for considering fungal causes in sellar mass diagnoses.

Keywords:
AspergillusFungal infectionPituitary gland

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Endocrinology

Background:

  • Pituitary and sellar masses typically warrant investigation for neoplastic or vascular causes.
  • Fungal infections of the pituitary gland and sella are exceptionally rare but should be considered in differential diagnoses.

Observation:

  • A 74-year-old male with multiple comorbidities presented with neurological deficits and was found to have a sellar region abnormality.
  • Despite extensive workup, an infectious etiology was not identified during the patient's clinical course.
  • Autopsy revealed necrotizing meningitis with angioinvasive Aspergillus hyphae in the sellar region.

Findings:

  • The autopsy confirmed Aspergillus species as the causative agent of infection in the pituitary gland and sella.
  • The patient's presentation mimicked vasculitis, underscoring the diagnostic challenge of rare infections.
  • Unlike typical presentations, this patient was not immunocompromised.

Implications:

  • Early consideration of fungal infections in sellar mass differentials is crucial for timely diagnosis and treatment.
  • A transsphenoidal surgical approach may be beneficial in suspected cases to prevent infection spread.
  • Antifungal therapy can be effective in managing Aspergillus infections of the pituitary and sella.