Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neural Regulation01:37

Neural Regulation

44.7K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
44.7K
Hormones Secreted by the Stomach01:25

Hormones Secreted by the Stomach

3.1K
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
3.1K
Regulation of the Digestive System01:25

Regulation of the Digestive System

3.8K
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
3.8K
Gut-Brain Axis01:22

Gut-Brain Axis

39
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
39
Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists01:28

Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists

740
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy.  SP binds and activates...
740
Hormonal Regulation01:40

Hormonal Regulation

50.3K
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
50.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Characteristics, management, and outcomes of patients with VIPoma-A retrospective analysis of the ENETS database.

Journal of neuroendocrinology·2026
Same author

Survival of patients managed in France for duodenal neuroendocrine tumors (D-NET): a 20-year multicenter cohort study from the GTE group: a cohort study.

International journal of surgery (London, England)·2024
Same author

Reperfused human cadaver as a new simulation model for colonoscopy: a pilot study.

Surgical endoscopy·2022
Same author

Aseptic splenic abscesses as the inaugural manifestation of Crohn's disease.

Clinics and research in hepatology and gastroenterology·2022
Same author

Time from first seen in specialist care to surgery does not influence survival outcome in patients with upfront resected pancreatic adenocarcinoma.

BMC surgery·2021
Same author

Prognosis of poorly cohesive gastric cancer after complete cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (CYTO-CHIP study).

The British journal of surgery·2021

Related Experiment Video

Updated: Mar 25, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
09:43

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

7.0K

[Digestive neuroendocrine tumors].

L de Mestier1, S Deguelte-Lardière2, H Brixi1

  • 1Service d'hépato-gastroentérologie et de cancérologie digestive, hôpital Robert-Debré, avenue du Général-Koenig, 51026 Reims cedex, France.

La Revue De Medecine Interne
|February 22, 2016
PubMed
Summary

Digestive neuroendocrine tumors (NETs) are rare, increasingly diagnosed, and often advanced. Diagnosis and grading rely on pathology, while imaging and Chromogranin A aid detection and staging for tailored treatment.

Keywords:
Carcinoid tumorsDiagnosisDiagnosticNeuroendocrine tumorsTraitementTreatmentTumeurs carcinoïdesTumeurs neuroendocrines

More Related Videos

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

19.2K

Related Experiment Videos

Last Updated: Mar 25, 2026

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids
09:43

Establishment and Characterization of Small Bowel Neuroendocrine Tumor Spheroids

Published on: October 14, 2019

7.0K
A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice
08:55

A Practical Guide for the Production and PET/CT Imaging of 68Ga-DOTATATE for Neuroendocrine Tumors in Daily Clinical Practice

Published on: April 17, 2019

19.2K

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Digestive neuroendocrine tumors (NETs) represent a rare but increasingly diagnosed malignancy.
  • Often diagnosed at advanced stages due to nonspecific symptoms and potential hormone hypersecretion.
  • Accurate pathological analysis is crucial for diagnosis, grading (differentiation, proliferation index), and prognosis.

Purpose of the Study:

  • To provide a comprehensive overview of the diagnosis, staging, and management of digestive neuroendocrine tumors.
  • To highlight key diagnostic markers, imaging techniques, and prognostic factors.
  • To discuss current and emerging therapeutic strategies for localized and metastatic NETs.

Main Methods:

  • Review of pathological diagnostic criteria including differentiation and proliferation indices.
  • Evaluation of biochemical markers such as Chromogranin A.
  • Assessment of conventional (CT, MRI) and advanced imaging modalities (somatostatin-receptor scintigraphy, positron-emitting scintigraphy).

Main Results:

  • Digestive NETs often present late with nonspecific symptoms or hormone hypersecretion.
  • Chromogranin A is the primary biochemical marker; advanced imaging is evolving.
  • Prognostic factors include tumor stage, metastatic burden, differentiation, and grade.

Conclusions:

  • Management strategies for digestive NETs are complex, depending on tumor location, grade, stage, and metastatic spread.
  • Treatment options range from resection to somatostatin analogs, chemotherapy, targeted therapies, and radionuclide therapy.
  • Multidisciplinary management is essential to balance efficacy with cumulative toxicity in patients with prolonged survival.