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Published on: February 19, 2013
Pathogenicity of Fusobacterium necrophorum biovar C in mice by intraperitoneal and intraportal injections
Abstract:
Three strains of Fusobacterium necrophorum biovar C were injected into mice intraperitoneally and intraportally. All the mice survived. In one mouse out of 15 mice injected intraperitoneally, a few focal abscesses were formed in the liver. The microorganisms were recovered from the liver abscess and the tissue of liver with abscess. No changes were observed in the organs of other 14 mice and no bacteria were recovered from them. In the 15 mice injected intraportally, no liver abscesses and no macroscopic changes in the organs were formed. However, the inoculated bacteria were recovered from the liver of four mice. The pathogenicity of F. necrophorum biovar C was weaker than that of other two biovars.
Insights
Fusobacterium necrophorum biovar C showed low pathogenicity in mice, with minimal liver abscess formation. This strain was less virulent compared to other Fusobacterium necrophorum biovars in experimental models.
Area of Science:
- Microbiology
- Veterinary Pathology
Background:
- Fusobacterium necrophorum is an anaerobic bacterium known to cause abscesses in various animal species.
- Different biovars of F. necrophorum may exhibit varying degrees of virulence.
Purpose of the Study:
- To evaluate the pathogenicity of Fusobacterium necrophorum biovar C in a murine model.
- To compare the virulence of F. necrophorum biovar C with other biovars.
Main Methods:
- Three strains of F. necrophorum biovar C were administered intraperitoneally and intraportally to mice.
- Mice were monitored for survival and clinical signs.
- Organs were examined for macroscopic changes and bacterial recovery.
Main Results:
- All mice survived the experimental inoculation.
- One mouse developed focal liver abscesses after intraperitoneal injection, with bacterial recovery from abscess tissue.
- Intraportal injection resulted in no macroscopic changes, but bacteria were recovered from the liver in four mice.
- Fusobacterium necrophorum biovar C demonstrated lower pathogenicity compared to other biovars.
Conclusions:
- Fusobacterium necrophorum biovar C exhibits limited pathogenicity in mice via intraperitoneal and intraportal routes.
- The virulence of F. necrophorum biovar C is notably weaker than other identified biovars.
