Comparison of recovery parameters for xenon versus other inhalation anesthetics: systematic review and meta-analysis
Bingzong Hou1, Fujing Li2, Shanshan Ou2
1Department of General Surgery, Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52 East Meihua Road, Zhuhai, Guangdong 519000, China.
Study Objective:
To summarize and evaluate the available data describing the recovery parameters of xenon anesthesia.
Design:
Systematic review and meta-analysis.
Setting:
Anesthesia for elective surgeries.
Patients:
Systematic review of randomized controlled trials (RCTs) from databases including Medline (1964-2013), the Cochrane Central Register of Controlled Trials (CENTRAL, 1990-2012), and Google Scholar (1966-2013).
Interventions:
Inhalation of xenon or other anesthetics was administered in elective surgery.
Measurements:
Recovery parameters (time to recovery, alertness/sedation scale scores at "eye opening," bispectral index at "reaction on demand," time to extubation, and time to orientation).
Main Results:
Eleven RCTs (N = 661 patients) met the inclusion criteria. Recovery from xenon anesthesia was significantly faster in terms of the time to eye opening (mean difference [MD], -4.18 minutes; 95% confidence interval [CI], -5.03 to -3.32 minutes; P < .00001), the time to reaction on demand (MD, -5.35 minutes; 95% CI, -6.59 to -4.11 minutes; P < .00001), the time to extubation (MD, -4.49 minutes; 95% CI, -5.40 to -3.58 minutes; P < .00001), and the time to orientation (MD, -4.99 minutes; 95% CI, -6.45 to -3.52 minutes; P < .00001).
Conclusions:
This meta-analysis confirmed that recovery from xenon anesthesia is faster than other inhalation anesthesia.
More Related Videos
09:36Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
Published on: September 24, 2020
04:56In Vitro Method to Control Concentrations of Halogenated Gases in Cultured Alveolar Epithelial Cells
Published on: October 23, 2018
Related Concept Videos
Inhalational Anesthetics: Overview
Stages of General Anesthesia
Parenteral Anesthetics: Overview
General Anesthesia: Overview
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
