The electrophysiology of the GnRH pulse generator in the rhesus monkey

The electrophysiological correlates of hypothalamic GnRH pulse generator activity in the rhesus monkey are described. They are characterized by abrupt increases in neuronal multiunit electrical activity (volleys) that are coincident with the initiation of LH pulses in the peripheral circulation. Both the frequency and duration of these volleys can be varied by a variety of endocrinological, pharmacological and environmental perturbations. Their activity throughout the rhesus monkey menstrual cycle as assessed by radiotelemetry is described.