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Related Experiment Video

Updated: Mar 25, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

Published on: December 25, 2021

Circulating tumor cell technologies.

Meghaan M Ferreira¹, Vishnu C Ramani¹, Stefanie S Jeffrey¹

¹Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.

Molecular Oncology

|February 22, 2016

Summary

Detecting circulating tumor cells (CTCs) via liquid biopsy is key for cancer therapy. This review covers current CTC detection and isolation technologies, their strategies, and challenges for clinical application.

Keywords:

Antigen-independent enrichment CTC capture CTC clusters Cancer Immunoaffinity enrichment

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Last Updated: Mar 25, 2026

Circulating Tumor Cell Lines: an Innovative Tool for Fundamental and Translational Research

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Capture and Release of Viable Circulating Tumor Cells from Blood

Capture and Release of Viable Circulating Tumor Cells from Blood

Published on: October 28, 2016

Area of Science:

Oncology
Biotechnology
Cancer Diagnostics

Background:

Circulating tumor cells (CTCs) are rare cells found in blood, offering a non-invasive window into cancer.
Liquid biopsy using CTCs has significant potential to revolutionize cancer detection, monitoring, and treatment.
Current challenges include reliably detecting and isolating these rare cells for further analysis.

Purpose of the Study:

To provide a comprehensive overview of existing technologies for CTC detection and capture.
To analyze the strategies and advantages of various CTC isolation platforms.
To discuss the evolving landscape of CTC biology and its impact on technology development.

Main Methods:

Review of current scientific literature and technological platforms for CTC detection.
Analysis of methods based on physical properties (size, density, deformability) and biological markers.
Examination of microfluidic devices, immunomagnetic separation, and filtration techniques.

Main Results:

Multiple technologies exist for CTC detection and isolation, each with unique strengths and limitations.
Platforms vary in their ability to capture CTCs based on different biological and physical characteristics.
Recent data highlights the importance of epithelial-to-mesenchymal transition (EMT), tumor-initiating cells, and CTC clusters.

Conclusions:

Advancements in CTC detection technologies are crucial for realizing the clinical potential of liquid biopsies.
Future developments must address challenges related to CTC heterogeneity and complex biology.
Evolving CTC technologies are essential for personalized cancer therapy and improved patient outcomes.