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Updated: Mar 25, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
[THE WORLD EXPERIENCE OF THE PEDIATRIC INTESTINAL FAILURE PROGRAM: SUCCESSFUL OUTCOMES FROM INTESTINAL
Insights
Pediatric short bowel syndrome management is optimized through coordinated care, including nutrition support and transplantation. Early intervention at specialized centers improves outcomes for infants with intestinal failure.
Area of Science:
- Pediatric gastroenterology and surgery
- Intestinal failure and rehabilitation
Context:
- Short bowel syndrome (SBS) presents complex challenges in pediatric patients.
- Effective management requires a multidisciplinary approach involving nutrition, medical, and surgical interventions.
- The establishment of Pediatric Intestinal Failure Centers and the Pediatric Intestinal Failure Consortium signifies a concerted effort to improve care.
Purpose:
- To define optimal management strategies for pediatric intestinal failure.
- To evaluate the effectiveness of interdisciplinary care models in improving long-term outcomes.
- To assess the impact of specialized intestinal rehabilitation centers on patient survival and treatment efficacy.
Summary:
- Management of pediatric short bowel syndrome is optimized through coordinated parenteral/enteral nutrition, complication management, surgical procedures, and transplantation.
- Prospective studies by the Pediatric Intestinal Failure Consortium suggest intestinal failure is treatable, advocating for aggressive management and early referral to rehabilitation centers.
- Integration with transplant services has led to earlier assessment, reduced transplantation rates, and decreased liver failure mortality.
Impact:
- Demonstrates excellent survival rates in complex pediatric intestinal failure cases.
- Highlights the treatability of pediatric intestinal failure with dedicated, aggressive management.
- Supports the early referral of at-risk infants to specialized intestinal rehabilitation centers for improved outcomes.
Abstract:
Management of children with short bowel syndrome is optimized by interdisciplinary coordination of parenteral and enteral nutrition support, medical management of associated complications, surgical lengthening procedures, and intestinal transplantation. Pediatric Intestinal Failure Centers were established in 14 pediatric hospitals throughout the United States and Canada and the Pediatric Intestinal Failure Consortium has been developed and is implementing prospective, multi-institutional studies to better define the specific aspects of intestinal failure management that optimize long-term outcomes. The published data from these studies suggest that intestinal failure in pediatric patients is quite treatable and provides further evidence that all infants at risk for intestinal failure should be treated aggressively and referred early to a dedicated intestinal rehabilitation center. Improved communication and integration with the transplant service have resulted in earlier assessment, decreased rates of transplantation, and decreased mortality from liver failure. The data presented demonstrates that a newly established intestinal failure program can achieve excellent survival in a cohort of chronically ill and complex pediatric cases that have historically been associated with substantial mortality.
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