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Sofosbuvir and ledipasvir for HIV/HCV co-infected patients

Elana S Rosenthal1, Shyam Kottilil2, Michael A Polis3

  • 1a Clinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc. , Frederick National Laboratory for Cancer Research , Frederick , MD , USA.

Expert Opinion on Pharmacotherapy
|February 23, 2016
PubMed

Insights

Direct-acting antivirals like ledipasvir and sofosbuvir (LDV/SOF) offer highly effective Hepatitis C virus (HCV) treatment for individuals with HIV co-infection. Further research is needed for specific populations and treatment durations.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Virology

Background:

  • Hepatitis C virus (HCV) infection poses a significant health challenge for individuals living with HIV.
  • Historically, treating HCV in HIV-co-infected patients was less effective.
  • Direct-acting antivirals (DAAs) have transformed HCV treatment outcomes.

Purpose of the Study:

  • To review the efficacy of ledipasvir and sofosbuvir (LDV/SOF) for HCV treatment in HIV co-infected patients.
  • To provide evidence-based context for using LDV/SOF in this population.

Main Methods:

  • Literature review of articles indexed in MEDLINE/PubMed.
  • Focused on studies concerning LDV/SOF for HCV treatment in co-infected individuals.

Main Results:

  • LDV/SOF demonstrates high efficacy in achieving sustained virologic response (SVR) for HCV.
  • The treatment is effective in patients with HIV and HCV co-infection.

Conclusions:

  • Ledipasvir and sofosbuvir (LDV/SOF) is a highly effective treatment for achieving HCV cure.
  • Further investigation is required regarding efficacy in uncontrolled HIV, drug interactions with antiretrovirals, and optimized treatment durations.
Abstract

Keywords:
HIV/HCV co-infectionHepatitis C virusdirect-acting antiviralsledipasvir/sofosbuvir

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