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Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A

Hyemin Kim1,2, Mirim Jang1, Yejin Kim1

  • 1Laboratory of Vitamin C and Antioxidant Immunology, Department of Anatomy, Seoul National University College of Medicine, Seoul, Korea.

The Journal of Pharmacy and Pharmacology
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Red ginseng and vitamin C boost immune cell activity and fight viral infections. Supplementation improved survival rates and reduced lung inflammation in mice infected with influenza A virus.

Keywords:
H1N1influenza A virusred ginsengvitamin C

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Area of Science:

  • Immunology
  • Virology
  • Nutritional Science

Background:

  • Red ginseng and vitamin C possess known immunomodulatory and antiviral properties.
  • Investigating synergistic effects of these compounds on immune response and viral suppression is warranted.

Purpose of the Study:

  • To determine if red ginseng and vitamin C synergistically enhance immune cell function.
  • To assess the combined effect of red ginseng and vitamin C in suppressing viral infection.

Main Methods:

  • Human peripheral blood mononuclear cells (PBMCs) and KSHV-infected BCBL-1 cells were treated with red ginseng and vitamin C.
  • Gulo(-/-) mice, unable to synthesize vitamin C, were administered red ginseng and vitamin C, with or without influenza A virus/H1N1 infection.

Main Results:

  • Red ginseng and vitamin C increased CD25 and CD69 expression on PBMCs and natural killer (NK) cells.
  • Co-treatment reduced cell viability and lytic gene expression in KSHV-infected cells.
  • In mice, supplementation enhanced NKp46 expression and interferon-γ production, reducing influenza-induced lung inflammation and increasing survival.

Conclusions:

  • Red ginseng and vitamin C administration enhance T and NK cell activation.
  • These compounds repress viral lytic cycle progression and mitigate viral-induced lung inflammation.
  • Supplementation with red ginseng and vitamin C increases survival rates during viral infections.