Related Experiment Video

Updated: Mar 25, 2026

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

8.5K

Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2014

Katherine I Calderón1, María Díaz-de Cerio1, Almudena Otero1

  • 1Enterovirus Unit, National Centre for Microbiology, National Health Institute "Carlos III", Ctra. Majadahonda-Pozuelo km 2, Madrid, Spain.

Archives of Virology
|February 23, 2016
PubMed

Insights

Coxsackievirus B3 infections primarily affected infants in Spain, causing neurological and respiratory illnesses. Genotype evolution and recombination were observed in this enterovirus (EV) type.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Enterovirus (EV) infections pose a significant public health concern.
  • Coxsackievirus B3 (CVB3) is a notable enterovirus with diverse clinical manifestations.
  • Understanding the epidemiology and genetic diversity of CVB3 is crucial for disease control.

Purpose of the Study:

  • To investigate the epidemiological and clinical features of Coxsackievirus B3 infections in Spain.
  • To analyze the genetic evolution and phylogenetic characteristics of circulating CVB3 strains.
  • To identify potential recombination events in the CVB3 genome.

Main Methods:

  • Retrospective epidemiological and clinical data analysis.
  • Molecular detection and typing of enterovirus (EV).
  • Phylogenetic analysis of the VP1 and 3D regions of the CVB3 genome.

Main Results:

  • Coxsackievirus B3 (CVB3) infections were predominantly identified in infants (<6 months).
  • Neurological (78%) and respiratory (10%) diseases were the most common clinical outcomes; myo/pericarditis occurred in 10% of cases, with two fatal myocarditis instances.
  • Phylogenetic analysis revealed a shift from CVB3 genotype III (2004-2008) to genotype V (2010).
  • Evidence of recombination events was detected in the 3D region, indicating ongoing viral evolution.

Conclusions:

  • Coxsackievirus B3 (CVB3) poses a significant risk to young children in Spain, primarily causing neurological and respiratory illness.
  • The genetic landscape of CVB3 in Spain has evolved, with genotype shifts and recombination influencing its epidemiology.
  • Continued surveillance and molecular characterization are essential for understanding and managing CVB3 infections.

More Related Videos

Cost-effective Method for Microbial Source Tracking Using Specific Human and Animal Viruses11:29

Cost-effective Method for Microbial Source Tracking Using Specific Human and Animal Viruses

Published on: December 3, 2011

12.7K
Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency18:10

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

Published on: June 16, 2011

30.2K

Related Concept Videos

Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
34
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
19
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
31
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
14
Statistical Methods for Analyzing Epidemiological Data01:25

Statistical Methods for Analyzing Epidemiological Data

Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
1.2K
Principles of Disease Surveillance01:26

Principles of Disease Surveillance

Disease surveillance is the systematic collection, analysis, and interpretation of health data essential to the planning, implementation, and evaluation of public health practice. This process integrates data dissemination to entities responsible for preventing and controlling disease, injury, and disability. Surveillance systems provide crucial information for action, helping public health authorities make informed decisions to manage and prevent outbreaks, ensure public safety, optimize...
785