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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

112
Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
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Polymeric Based Therapeutic Delivery Systems Prepared Using Electrohydrodynamic Processes.

M Rasekh, K Nazari, M S Arshad

  • 1State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, P.R. China. xiang.li@zju.edu.cn.

Current Pharmaceutical Design
|February 23, 2016
PubMed
Summary
This summary is machine-generated.

Electrohydrodynamic (EHDA) engineering offers advanced methods for creating pharmaceutical and biomaterial excipients using polymers. These scalable technologies enable fabrication of diverse structures for drug delivery and tissue engineering applications.

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Area of Science:

  • Polymer science and engineering
  • Pharmaceutical technology
  • Biomaterials science

Background:

  • Polymeric excipients are crucial in therapeutic dosage systems, offering functions like controlled release and adhesion.
  • Synthetic polymers (e.g., PCL, PLGA) and natural polymers (e.g., lactose, gelatin) are widely used.
  • Advances in processing technologies like spray drying and microfluidics enable novel material structures.

Purpose of the Study:

  • To review key developments in electrohydrodynamic (EHDA) engineering for pharmaceutical and biomaterial applications.
  • To discuss the principles, parameters, and variables of EHDA processes.
  • To highlight the potential of EHDA in fabricating polymeric excipients.

Main Methods:

  • Focus on electrohydrodynamic (EHDA) engineering techniques.
  • Review of synthetic and naturally occurring polymers as pharmaceutical excipients.
  • Discussion of EHDA process principles, material, and engineering parameters.

Main Results:

  • EHDA technologies can fabricate diverse structures (particles, fibers, patterns) across various scales.
  • EHDA processes operate at ambient conditions and are viable for large-scale production.
  • EHDA shows promise for established applications (films, dressings) and emerging fields (nanomedicines, tissue engineering).

Conclusions:

  • EHDA engineering presents a robust platform for developing advanced polymeric excipients.
  • These technologies offer versatile fabrication capabilities for pharmaceutical and biomaterial applications.
  • EHDA is a promising approach for both current and future therapeutic system development.