Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Production of Pharmaceuticals01:30

Production of Pharmaceuticals

26
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under...
26
Recombinant DNA01:09

Recombinant DNA

104.7K
Overview
104.7K
Upstream Processing01:27

Upstream Processing

36
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
36
The Central Dogma01:20

The Central Dogma

35.2K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
35.2K
Proteins: From Genes to Degradation02:11

Proteins: From Genes to Degradation

14.9K
Within a biological system, the DNA encodes the RNA, and the nucleotide sequence in the RNA further defines the amino acid sequence in the protein. This is referred to as “The Central Dogma of Molecular Biology” - a term coined by Francis Crick.  Central dogma is a firm principle in biology that defines the flow of genetic information within any life form. The two fundamental steps in central dogma are - transcription and translation.
Transcription is the synthesis of RNA...
14.9K
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

107
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
107

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of spacer length and flexibility in peptide self-assembly.

Beilstein journal of organic chemistry·2026
Same author

Polydopamine-polyethylene glycol-liproxstatin-1 nanoparticles inhibit ferroptosis for enhanced treatment of neutrophilic asthma.

Frontiers in pharmacology·2026
Same author

Flap reconstruction versus primary perineal closure after abdominoperineal resection: a systematic review and meta-analysis.

Updates in surgery·2026
Same author

Reversible Nucleolar Complex Coacervation by Short Cationic Peptides.

Journal of the American Chemical Society·2026
Same author

<i>Maackia amurensis</i> seed lectin inhibits oral squamous cell carcinoma tumorigenesis by suppressing N6-methyladenosine modification-mediated SRY-box transcription factor 2 expression.

The Journal of international medical research·2026
Same author

Intelligent fall risk prediction and real-time warning system for elderly care based on multimodal deep learning and wearable sensor fusion.

Scientific reports·2026
Same journal

Role of Phenolic Nanocompounds in Inflammatory Disorders: Current View and Future Aspects.

Current pharmaceutical design·2026
Same journal

Overcoming Physiological Barriers in Brain Tumor Therapy: Advances in Nanomedicine, Ultramolecular Pharmaceuticals, and Targeted Drug Delivery.

Current pharmaceutical design·2026
Same journal

Breathing Life into Research: The Transformative Potential of Lung-on-a-Chip Technology.

Current pharmaceutical design·2026
Same journal

Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.

Current pharmaceutical design·2026
Same journal

Emerging Role of AI in Gastroenterology and Hepatology: Revolutionizing Medical Device-Assisted Diagnosis.

Current pharmaceutical design·2026
Same journal

Nanostructured Lipid Carriers in Drug Targeting: Characterization, Patents, and Recent Innovations.

Current pharmaceutical design·2026
See all related articles

Related Experiment Video

Updated: Mar 25, 2026

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

7.2K

Converting Human Proteins into Precision Polymer Therapeutics.

Felix Boldt, Weina Liu, Yuzhou Wu1

  • 1Department of Organic Chemistry III/Macromolecular Chemistry, Ulm University, Albert-Einstein- Allee 11, 89081 Ulm, Germany. yuzhou.wu@uni-ulm.de.

Current Pharmaceutical Design
|February 23, 2016
PubMed
Summary
This summary is machine-generated.

Researchers are developing novel biohybrid polymers by combining protein and synthetic elements. These advanced materials offer precise control over structure and function for biomedical applications like drug delivery and biosensing.

More Related Videos

Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
07:35

Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli

Published on: June 9, 2014

22.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Related Experiment Videos

Last Updated: Mar 25, 2026

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy
08:34

OaAEP1-Mediated Enzymatic Synthesis and Immobilization of Polymerized Protein for Single-Molecule Force Spectroscopy

Published on: February 5, 2020

7.2K
Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli
07:35

Non-chromatographic Purification of Recombinant Elastin-like Polypeptides and their Fusions with Peptides and Proteins from Escherichia coli

Published on: June 9, 2014

22.6K
Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
14:20

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

17.2K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Synthetic Biology

Background:

  • Cells utilize complex macromolecules and supramolecular interactions for vital functions.
  • Achieving precise control over synthetic polymer architecture and sequence remains a significant challenge.
  • Biomedical applications demand polymers with reproducible synthesis, narrow dispersities, tunable functionalities, and biocompatibility.

Purpose of the Study:

  • To review recent advances in polymeric biohybrid materials.
  • To highlight the advantages of combining protein precursors with synthetic polymers.
  • To explore the potential of these materials in various biomedical fields.

Main Methods:

  • Review of recent literature on polymeric biohybrid materials.
  • Analysis of synthesis strategies for combining protein and synthetic polymer components.
  • Discussion of characterization techniques for evaluating material properties.

Main Results:

  • Polymeric biohybrid materials leverage the precise sequences of proteins and the tunable properties of synthetic polymers.
  • These materials exhibit enhanced biocompatibility, biodegradability, and controlled functionalities.
  • Recent advances enable precise control over polymer architecture and supramolecular assembly.

Conclusions:

  • Polymeric biohybrid materials represent a promising platform for advanced biomedical applications.
  • Combining protein and synthetic polymer features offers synergistic advantages over traditional materials.
  • Future research will likely focus on expanding the complexity and application scope of these materials.