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Inflammation

Inflammation

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

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Quantitative Analysis and Characterization of Atherosclerotic Lesions in the Murine Aortic Sinus

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Published on: December 7, 2013

Macrophage miRNAs in atherosclerosis.

Denuja Karunakaran¹, Katey J Rayner²

¹University of Ottawa Heart Institute, Ottawa, Canada.

Biochimica Et Biophysica Acta

|February 23, 2016

Summary

MicroRNAs (miRNAs) are small RNAs regulating gene expression and biological processes. These molecules show promise as therapeutic targets for cardiometabolic diseases like atherosclerosis.

Keywords:

Atherosclerosis Cholesterol efflux Inflammation Macrophage MicroRNA Therapeutic

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Area of Science:

Molecular Biology
Genetics
Biochemistry

Background:

Endogenous microRNAs (miRNAs) are small, non-coding RNAs discovered in the 1990s.
Hundreds of miRNAs have been identified, regulating diverse biological processes like proliferation, apoptosis, and metabolism.
miRNAs act as "rheostats" to modulate gene expression within genetic networks.

Purpose of the Study:

To explore the role of miRNAs in regulating biological processes.
To highlight the potential of miRNAs as therapeutic targets for cardiometabolic diseases.
To discuss the mechanistic regulation of genetic networks by miRNAs.

Main Methods:

Identification and characterization of miRNAs.
Analysis of miRNA function in various biological processes.
Investigation of miRNA roles in health and disease states.

Main Results:

miRNAs are crucial regulators of multiple genes and biological functions.
Dysregulation of miRNAs is implicated in pathological conditions, including cardiometabolic diseases.
Atherosclerosis progression is influenced by specific miRNAs, suggesting therapeutic potential.

Conclusions:

Understanding miRNA mechanisms offers new therapeutic avenues for diseases like atherosclerosis, diabetes, and obesity.
Further research is needed to fully decipher the complexities of miRNA-mediated genetic network regulation.
miRNAs represent promising targets for novel interventions in cardiometabolic disease treatment.