Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diversion colitis: a nutritional deficiency syndrome?

V P Agarwal, E M Schimmel

    Nutrition Reviews
    |September 1, 1989
    PubMed
    Summary

    Diversion colitis, an inflammatory condition, may be a nutritional deficiency. Treating patients with short-chain fatty acids (SCFA) via colonic instillation successfully resolved symptoms, suggesting SCFA are crucial for colonic health.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The hazards of hospitalization. 1964.

    Quality & safety in health care·2003
    Same author

    Proton MR spectroscopic measurement of neurometabolites in hepatic encephalopathy during oral lactulose therapy.

    AJNR. American journal of neuroradiology·1998
    Same author

    High prevalence of chronic gastrointestinal symptoms in a National Guard Unit of Persian Gulf veterans.

    The American journal of gastroenterology·1996
    Same author

    Gastric pH after cetacaine spray.

    The American journal of gastroenterology·1990
    Same author

    Multiple esophageal rings.

    Gastrointestinal endoscopy·1990
    Same author

    Endoscopic evaluation of heterotopic pancreas.

    Gastrointestinal endoscopy·1989

    Area of Science:

    • Gastroenterology
    • Cell Biology
    • Nutritional Science

    Background:

    • Colonic epithelial cells rely on lumenal short-chain fatty acids (SCFA) for energy.
    • SCFA, produced by bacterial fermentation, are key solutes in colonic contents.
    • N-butyric acid is the preferred energy source for colonocytes.

    Purpose of the Study:

    • To review evidence suggesting diversion colitis is a nutritional deficiency syndrome.
    • To explore the local mucosal requirement for SCFA in the colon.

    Main Methods:

    • Literature review of studies on SCFA and colonic health.
    • Case study of four patients with diversion colitis treated with SCFA instillation.

    Main Results:

    • Successful treatment of diversion colitis in four patients using mixed SCFA colonic instillation.
    • Evidence supports SCFA as essential for colonic mucosal health.

    Conclusions:

    • Diversion colitis may represent a novel nutritional deficiency syndrome.
    • Local SCFA availability is critical for maintaining colonic mucosal integrity and function.

    Related Experiment Videos