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Updated: Mar 25, 2026

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
10:03

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iPSCs Derived from Malignant Tumor Cells: Potential Application for Cancer Research

He Cheng, Chen Liu, Xiaochen Cai

  • 1No. 270, Dong An Road, Xuhui District, Shanghai, 200032, P.R. China. yuxianjun@fudanpci.org.

Current Stem Cell Research & Therapy
|February 23, 2016
PubMed

Insights

Induced pluripotent stem cells (iPSCs) derived from malignant cells offer new avenues for cancer research. Tumor iPSCs are valuable for studying cancer mechanisms, developing disease models, and screening drugs.

Area of Science:

  • Stem Cell Biology
  • Cancer Research
  • Molecular Biology

Background:

  • Induced pluripotent stem cell (iPSC) technology allows cell fate manipulation and disease insight.
  • Reprogramming somatic cells into iPSCs is well-studied.
  • Reprogramming of malignant cells remains underexplored.

Purpose of the Study:

  • To review recent advancements in iPSCs derived from malignant cells.
  • To highlight the applications of tumor iPSCs in cancer research.

Main Methods:

  • Review of existing literature on malignant cell reprogramming and iPSC derivation.
  • Analysis of tumor iPSC applications in key areas of cancer research.

Main Results:

  • Progress in generating iPSCs from various malignant cell types.
  • Tumor iPSCs are instrumental in studying mesenchymal-epithelial transition.
  • Applications include genetic/epigenetic analysis, disease modeling, drug screening, and pathway studies.

Conclusions:

  • Tumor iPSCs represent a promising tool for advancing cancer research.
  • Further investigation into tumor iPSC reprogramming and applications is warranted.

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