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Updated: Mar 25, 2026

Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes
Published on: November 11, 2016
iPSCs Derived from Malignant Tumor Cells: Potential Application for Cancer Research
He Cheng, Chen Liu, Xiaochen Cai
1No. 270, Dong An Road, Xuhui District, Shanghai, 200032, P.R. China. yuxianjun@fudanpci.org.
Abstract:
The development of induced pluripotent stem cell (iPSC) technology has inspired a series of methods to manipulate cell fate and has provided novel insight into the profound molecular events underlying the development of diseases. Reprogramming somatic cells into iPSCs has been intensively investigated. However, few studies have investigated the reprogramming of malignant cells and its potential application. Herein, we review the recent progress of iPSCs derived from malignant cells, and highlight tumor iPSCs applications on cancer research which mainly focus on mesenchymal-epithelial transition, genetic and epigenetic change, diseases model construction, drug screening and tumor pathway study.
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