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Bone remodeling in pathologic conditions. A scanning electron microscopic study.

J Sela

    Calcified Tissue Research
    |October 20, 1977
    PubMed
    Summary
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    Scanning electron microscopy revealed distinct patterns of bone remodeling in various pathologic conditions. Pathologic bone resorption and neoplastic ossification showed unique microscopic features, offering insights into bone diseases.

    Area of Science:

    • Orthopedics
    • Pathology
    • Microscopy

    Background:

    • Bone remodeling is a complex process crucial for skeletal integrity.
    • Pathologic conditions can significantly alter normal bone remodeling.
    • Understanding these alterations is key to diagnosing and managing bone diseases.

    Purpose of the Study:

    • To investigate bone remodeling in pathologic conditions using scanning electron microscopy (SEM).
    • To characterize patterns of bone resorption and formation in various benign and malignant ossifications, tumors, and hormonal imbalances.

    Main Methods:

    • Utilized scanning electron microscopy (SEM) to examine bone samples.
    • Analyzed bone surfaces from cases including myositis ossificans, ossifying fibroma, osteosarcoma, squamous cell carcinoma, multiple myeloma, and acromegaly.

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    Main Results:

    • Pathologic bone resorption mimicked osteoclast-mediated resorption.
    • Neoplastic ossification exhibited characteristic calcifying globules (1-3 micron) with surfaces of minute calcospherites (0.1-0.3 micron).
    • Bone formation in acromegaly showed similarities to normal lamellar-cortical bone, with deformities linked to continuous osteogenesis.

    Conclusions:

    • SEM provides valuable insights into the microstructural changes of bone in diverse pathologic states.
    • The observed globular calcification patterns in neoplastic ossification may resemble those in fetal bone, cartilage, and fracture healing.
    • SEM can differentiate between normal and abnormal bone remodeling processes.