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Cingulate sulcus development in preterm infants.

T A Slagle1, M Oliphant, S J Gross

  • 1Department of Pediatrics, State University of New York-Health Science Center, Syracuse 13210.

Pediatric Research
|December 1, 1989
PubMed
Summary
This summary is machine-generated.

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Cranial ultrasounds reveal the in utero development of the cingulate sulcus in preterm infants. Severe brain injury can significantly delay this crucial brain development marker.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • The cingulate sulcus is a key anatomical landmark in the developing brain.
  • Understanding its in utero development is crucial for assessing fetal neurological health.

Purpose of the Study:

  • To characterize the in utero developmental sequence of the cingulate sulcus using cranial ultrasound.
  • To investigate the relationship between cingulate sulcus development and gestational age, as well as severe brain injury in preterm infants.

Main Methods:

  • Serial cranial ultrasounds were performed on 211 infants (24-40 wk gestational age) within the first 3 days of life.
  • Ultrasound findings of cingulate sulcus development were correlated with gestational age and the presence of severe brain insult (intraventricular hemorrhage, periventricular leukomalacia).

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Main Results:

  • The cingulate sulcus was identified between 24-28 wk gestational age, initially as fragmented echoes that coalesced and branched over time.
  • This developmental sequence mirrored postnatal cortical development and was independent of gestational age at birth.
  • Severe brain injury was significantly associated with delayed cingulate sulcus development at all stages.

Conclusions:

  • Cranial ultrasound provides a noninvasive method to assess in utero cingulate sulcus development and stage brain maturation.
  • Delayed cingulate sulcus development is a potential indicator of adverse neurological outcomes in preterm infants exposed to brain injury.